Dataset (8) : Pregnancy

Project Overview

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

   metagenomes   project metadata

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Static Link	http://metagenomics.anl.gov/linkin.cgi?project=265

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Description

Study abstract: Many of the immune and metabolic changes occurring during normal pregnancy also describe metabolic syndrome. Gutmicrobiota can cause symptoms of metabolic syndrome in nonpregnant hosts. Here, to explore their role in pregnancy, we characterized fecal bacteria of 91 pregnant women of varying prepregnancy BMIs and gestational diabetes status and their infants. Similarities between infant-mother microbiotas increased with children’s age, and the infant microbiota was unaffected by mother’s health status. Gut microbiota changed dramatically from first (T1) to third (T3) trimesters, with vast expansion of diversity between mothers, an overall increase in Proteobacteria and Actinobacteria, and reduced richness. T3 stool showed strongest signs of inflammation and energy loss; however, microbiome gene repertoires were constant between trimesters. When transferred to germ-free mice, T3 microbiota induced greater adiposity and insulin insensitivity compared to T1. Our findings indicate that hostmicrobial interactions that impact host metabolism can occur and may be beneficial in pregnancy.

Funding Source

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Contact

Administrative
Ruth Ley (rel222@cornell.edu)
Cornell University (http:// - )
Department of Microbiology, USA

Technical
- - ( - )
- (http:// - )
- , -

Metagenomes

There are 20 metagenomes in this project.

MG-RAST ID Metagenome Name  bp Count  Sequence Count  Biome  Feature  Material  Location  Country  Coordinates  Sequence Type  Sequence Method  Download 4474805.3 1601 2,436,548,256 24,449,696 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474369.3 1011 2,430,947,852 24,363,633 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474361.3 1013 1,886,783,614 18,900,012 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474360.3 1603 2,421,842,612 24,267,385 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474359.3 2261 2,039,733,107 20,385,087 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474358.3 2263 1,309,512,591 13,097,192 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474357.3 2371 1,949,147,406 19,531,233 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474355.3 3121 2,465,813,890 24,684,997 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474352.3 2373 1,571,015,061 15,766,776 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4474351.3 3123 2,320,563,935 23,207,774 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4469858.3 2264_new 6,138,616,600 61,386,167 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4467109.3 1342 8,565,365,200 85,653,652 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4466602.3 2342 11,763,734,200 117,637,342 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4466296.3 2234 12,202,712,400 122,027,124 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4466257.3 1234 8,703,383,200 87,033,832 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4466194.3 2303 8,317,590,200 83,175,902 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4466188.3 2195 11,283,563,600 112,835,636 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4466163.3 1195 10,334,623,700 103,346,237 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4466149.3 1264 5,575,340,200 55,753,402 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis 4466148.3 1303 11,959,947,400 119,599,474 terrestrial biome human-associated habitat feces Turku Finland 60.44925, 22.2592 WGS illumina metadata submitted analysis